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In cancer and aging, interconnected roles for apoptosis and cellular senescence

In cancer and aging, interconnected roles for apoptosis and cellular senescence

Researchers at the LBMCC review how these protective processes interact in cells' response to damage

A common feature of cancer and aging is cells' reduced ability to respond to stress-induced damage to DNA or cellular structu...

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Roles of Apoptosis and Cellular Senescence in Cancer and Aging

Claudia Cerella Cindy Grandjenette Mario Dicato Marc Diederich

Published in Current Topics in Medicinal Chemistry

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16469 0
Steps Toward Non-Toxic Cancer Therapy, with Help From the Sea

Steps Toward Non-Toxic Cancer Therapy, with Help From the Sea

A marine sponge could provide a new tumor-blocking drug and synergies with other therapies, Luxembourg researchers find.

Plants aren’t the only natural sources of potential new cancer treatments: a sea sponge has inspired the LBMCC lab’s latest a...

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Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent induci...

Cristina Florean Michael Schnekenburger Jin-Young Lee Kyung Kim Aloran Mazumder Sungmi Song Jae-Myun Kim Cindy Grandjenette Jeoung-Gyun Kim Ah-Young Yoon ...

Published in Oncotarget

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15407 0
Vers une thérapie non toxique contre le cancer, grâce à la mer

Vers une thérapie non toxique contre le cancer, grâce à la mer

Une éponge marine pourrait fournir un nouveau médicament capable de bloquer le développement de tumeurs et de créer des synergies avec d’autres thérapies, selon des chercheurs luxembourgeois.

Les plantes ne sont pas la seule source naturelle de traitements potentiels contre le cancer. Le laboratoire LBMCC s’est insp...

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Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent induci...

Cristina Florean Michael Schnekenburger Jin-Young Lee Kyung Kim Aloran Mazumder Sungmi Song Jae-Myun Kim Cindy Grandjenette Jeoung-Gyun Kim Ah-Young Yoon ...

Published in Oncotarget

Author

4224 0
Reining in Aggressive Prostate Cancer: Nature Provides Two Promising Inhibitors

Reining in Aggressive Prostate Cancer: Nature Provides Two Promising Inhibitors

Reducing the activity of a natural enzyme that gives cancer a boost could offer a viable new treatment strategy, according to results from the LBMCC in Luxembourg.

By blocking one of cancer’s accomplices in the body, researchers from the LBMCC lab at Kirchberg Hospital (Luxembourg) were a...

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4118 0
De la nature au chevet du patient : des molécules naturelles prometteuses contre le cancer de la prostate agressif

De la nature au chevet du patient : des molécules naturelles prometteuses contre le cancer de la prostate agressif

Réduire l’activité d’une enzyme qui stimule l’activité du cancer grâce à des inhibiteurs issus d’une plante médicinale pourrait présenter une nouvelle stratégie de traitement viable, d’après les recherches du LBMCC au Luxembourg.

En bloquant l’un des complices du cancer à l’intérieur du corps, des chercheurs du LBMCC à l’Hôpital du Kirchberg au Luxembou...

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3299 0
Avancées en Neuro-Oncologie : Vaincre la résistance aux traitements chez les enfants atteints du neuroblastome

Avancées en Neuro-Oncologie : Vaincre la résistance aux traitements chez les enfants atteints du neuroblastome

Une nouvelle étude luxembourgeoise laisse envisager un traitement personnalisé contre le neuroblastome, particulièrement résistant aux médicaments.

Un laboratoire de recherche luxembourgeois vient de publier ses découvertes récentes dans le prestigieux journal « Oncogene »...

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Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma

Flavia Radogna Claudia Cerella Anthoula Gaigneaux C. Christov Mario Dicato Marc Diederich

Published in Oncogene

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4792 0
Overcoming Drug Resistance in Childhood Neuroblastoma: Progress in Neuro-Oncology

Overcoming Drug Resistance in Childhood Neuroblastoma: Progress in Neuro-Oncology

A new study from Luxembourg could one day lead to personalized treatments for neuroblastoma, a notoriously drug-resistant form of cancer.

New findings from Luxembourg cancer lab LBMCC have the potential to help young children afflicted with a deadly form of cance...

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Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma

Flavia Radogna Claudia Cerella Anthoula Gaigneaux C. Christov Mario Dicato Marc Diederich

Published in Oncogene

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6068 0
For cancer, a natural or synthetic anti-inflammatory, but not both

For cancer, a natural or synthetic anti-inflammatory, but not both

A synthetic anti-inflammatory reduced the cancer-fighting effect of a well-known, natural compound found in turmeric.

While certain things are greater than the sum of their parts, this seems not to be the case with some cancer treatments. Rath...

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Celecoxib prevents curcumin-induced apoptosis in a hematopoietic cancer cell model

Cyril Sobolewski Florian Muller Claudia Cerella Mario Dicato Marc Diederich

Published in Molecular Carcinogenesis

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21554 0
Lutte contre le cancer : anti-inflammatoire naturel ou synthétique, il faut choisir !

Lutte contre le cancer : anti-inflammatoire naturel ou synthétique, il faut choisir !

Un anti-inflammatoire synthétique réduit l’action anticancéreuse d’une substance naturelle bien connue, extraite du curcuma

Si dans certaines situations, le tout est plus grand que la somme des parties, cela ne semble pas être le cas pour certains t...

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Celecoxib prevents curcumin-induced apoptosis in a hematopoietic cancer cell model

Cyril Sobolewski Florian Muller Claudia Cerella Mario Dicato Marc Diederich

Published in Molecular Carcinogenesis

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39733 0