Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptos...

Hélène Losson Gajulapalli, Sruthi Reddy Manon Lernoux Lee, Jin-Young Mazumder, Aloran Gérard, Déborah Seidel Carole Hahn, Hyunggu Christov, Christo Dicato, Mario ...

Published in Pharmacological Research

Despite the discovery of tyrosine kinase inhibitors (TKIs) for the treatment of breakpoint cluster region-Abelson (BCR-ABL) + cancer types, patients with chronic myeloid leukemia (CML) treated with TKIs develop resistance and severe adverse effects. Combination treatment, especially with a histone deacetylase (HDAC) 6 inhibitor (HDAC6i), appears to...

Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/M... PDF available through Get Fulltext Research

Lernoux, Manon Schnekenburger, Michael Losson, Hélène Vermeulen, Koen Hahn, Hyunggu Gérard, Déborah Lee, Jin-Young Mazumder, Aloran Ahamed, Muneer Christov, Christo ...

Published in Clinical Epigenetics

BackgroundChronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnormal constitutive tyrosine kinase activity, therapies using tyrosine kinase inhibitors (TKis) such as imatinib represent a major break...

Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia. PDF available through Get Fulltext Research

Sébastien Chateauvieux Gaigneaux, Anthoula Gérard, Déborah Marion Orsini Franck Morceau Barbora Orlikova Farge, Thomas Récher, Christian Sarry, Jean-Emmanuel Dicato, Mario ...

Published in Haematologica

No abstract available

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in ... PDF available through Get Fulltext Research

Marion Orsini Sébastien Chateauvieux Rhim, Jiyun Gaigneaux, Anthoula Cheillan, David Christov, Christo Dicato, Mario Franck Morceau Marc Diederich

Published in Cell Death and Differentiation

Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptos...

Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

Flavia Radogna Marc Diederich

Published in Biochemical Pharmacology

Cancer is evading the host's defense mechanisms leading to avoidance of immune destruction. During tumor progression, immune-evading cancer cells arise due to selective pressure from the hypoxic and nutrient-deprived microenvironment. Thus, therapies aiming at re-establishing immune destruction of pathological cells constitute innovating anti-cance...

Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c...

Esma Yagdi Aloran Mazumder Jin-Young Lee Anthoula Gaigneaux Flavia Radogna Muhammad Jawad Nasim Christo Christov Claus Jacob Kyu-Won Kim Mario Dicato ...

Published in Cancer Letters

Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...

Discovery and Characterization of R/S-N-3-Cyanophenyl-N'- (6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H- 1-ben...

Michael Schnekenburger Goffin, Eric Lee, Jin-Young Young Jang, Jun Mazumder, Aloran Ji, Seungwon Rogister, Bernard Bouider, Nafila Lefranc, Florence Miklos, Walter ...

Published in Journal of Medicinal Chemistry

A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. Based on computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyano...

Cardiac glycosides: From molecular targets to immunogenic cell death.

Diederich, Marc Muller, Florian Cerella, Claudia

Published in Biochemical pharmacology

Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase (NKA). Pharmacologically, they represent a well-known generation of drugs for treating cardiovascular problems, thus allowing the investigation of potential dose-depende...

Cardiac glycosides: From molecular targets to immunogenic cell death

Marc Diederich Florian Muller Claudia Cerella

Published in Biochemical Pharmacology

Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase (NKA). Pharmacologically, they represent a well-known generation of drugs for treating cardiovascular problems, thus allowing the investigation of potential dose-depende...

Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clin... PDF available through Get Fulltext Research

Losson, Hélène Schnekenburger, Michael Dicato, Mario Diederich, Marc

Published in Molecules

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