Integrated cellular pathology—Systems biology of human diseases
Published in Biochemical Pharmacology
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Erythropoietin, erythropoiesis and beyond
Published in Biochemical Pharmacology
Erythropoietin (EPO) is a glycoprotein that is mainly produced in the adult kidney, and it was initially highlighted for its action on the hematopoietic system. Moreover, EPO is also expressed in several non-hematopoietic tissues, where it plays a role in the protection from apoptosis and inflammation due to hypoxia, toxicity or injury. These prote...
Conference Scene: Omic technologies in human disease: extending the network of epigenetic control
Published in Epigenomics
The meeting 'Cell signal-omics 2011: integrated cellular pathology - systems biology of human disease' held on 26-28 January 2011 in Luxembourg, was organized by Recherches Scientifiques Luxembourg (RSL) under the auspices of the European Research Institute for Integrated Cellular Pathology. The meeting took place in the New Conference Center Kirch...
Epigenomics of leukemia: from mechanisms to therapeutic applications
Published in Epigenomics
Leukemogenesis is a multistep process in which successive transformational events enhance the ability of a clonal population arising from hematopoietic progenitor cells to proliferate, differentiate and survive. Clinically and pathologically, leukemia is subdivided into four main categories: chronic lymphocytic leukemia, chronic myeloid leukemia, a...
Gold from the sea: Marine compounds as inhibitors of the hallmarks of cancer
Published in Biotechnology Advances
Cancer is one of the most deadly diseases in the world. Although advances in the field of chemo-preventive and therapeutic medicine have been made regularly over the last ten years, the search for novel anticancer treatments continues. In this field, the marine environment, with its rich variety of organisms, is a largely untapped source of novel c...
The aromatic ketone 4′-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition
Published in Biochemical Pharmacology
Chalcones are aromatic ketones, known to exhibit anti-microbial, anti-inflammatory and anti-cancer activities. The aim of this study was to investigate the anti-inflammatory and anti-cancer activity of 4'-hydroxychalcone. Here, we report that 4'-hydroxychalcone inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner. To investigat...
Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis
Published in Journal of Cellular and Molecular Medicine
Histone deacetylases (HDACs) are important regulators of gene expression. Specific structural features and distinct regulative mechanisms rationalize the separation of the 18 different human HDACs into four classes. The class II comprises a heterogeneous group of nuclear and cytosolic HDACs involved in the regulation of several cellular functions, ...
Interactions of polysulfanes with components of red blood cells
...Published in MedChemComm
Traditionally, the activity of most polysulfanes has been associated with the redox behaviour of the sulfur-sulfur bond. Here we show that polysulfanes, such as diallyltri- and tetrasulfide, also interact with cellular membranes and certain metalloproteins. Together, multiple interactions with various biological targets may explain best the biologi...
Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 ove...
Published in Biochemical Pharmacology
Many physiological perturbations can cause anemia. In cancer patients, activation of the immune system leads to the production of proinflammatory cytokines including tumor necrosis factor alpha (TNFα), that have been shown to inhibit red-cell production via poorly understood mechanisms. Treatment of anemia by human recombinant erythropoietin (EPO) ...
Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 ove...
Published in Biochemical Pharmacology
