Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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34 News 229 Publications 14 Members 1 Events

Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3′,4′,5′-Pentamethoxyflavone Isolated from Lant...

Sawadogo, Wamtinga Al-Mourabit, Ali Moriou, Céline Guissou, Innocent Dicato, Mario Marie-Hélène Teiten Marc Diederich

Published in Nutrients

Lantana ukambensis (Vatke) Verdc. is an African food and medicinal plant. Its red fruits are eaten and highly appreciated by the rural population. This plant was extensively used in African folk medicinal traditions to treat chronic wounds but also as anti-leishmanial or cytotoxic remedies, especially in Burkina Faso, Tanzania, Kenya, or Ethiopia. ...

Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?

Michael Schnekenburger Marc Diederich

Published in Current Topics in Medicinal Chemistry

A majority of cancers display alterations in epigenetic mechanisms, such as aberrant DNA methylation at CpG islands (CGIs). This local hypermethy-lation of CGIs is associated with gene silencing leading to loss of tumor sup-pressor gene (TSG) functions that are critical for the control of tumor devel-opment. Concomitantly, global genomic hypomethyl...

Natural compounds and pharmaceuticals reprogram leukemia cell differentiation pathways

Franck Morceau Marc Diederich

Published in Biotechnology Advances

In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression....

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Gaascht, François Dicato, Mario Diederich, Marc

Published in Genes & Nutrition

Coffee is the second most popular beverage in the world after water with a consumption of approximately two billion cups per day. Due to its low cost and ease of preparation, it is consumed in almost all countries and by all social classes of the population through different modes of preparation. Despites its simple appearance, a cup of coffee is i...

Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments

Michael Schnekenburger Cristina Florean Dicato, Mario Marc Diederich

Published in Current Topics in Medicinal Chemistry

Despite considerable scientific progress, the burden of cancer in our society remains a major public health problem. Tumorigenesis is recognized as a complex and multistep process that involves the accumulation of successive transformational events with multi-factorial etiology. Nevertheless, such events result in the acquisition of key hallmark ch...

Role of Histone Acetylation in Cell Cycle Regulation

Miglena Koprinarova Michael Schnekenburger Marc Diederich

Published in Current Topics in Medicinal Chemistry

Core histone acetylation is a key prerequisite for chromatin decondensation and plays a pivotal role in regulation of chromatin structure, function and dynamics. The addition of acetyl groups disturbs histone/DNA interactions in the nucleosome and alters histone/histone interactions in the same or adjacent nucleosomes. Acetyl groups can also provid...

Editorial (Thematic Issue: Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic...

Michael Schnekenburger Cristina Florean Cindy Grandjenette Marc Diederich

Published in Current Topics in Medicinal Chemistry

Effects of Natural Products on Mcl-1 Expression and Function

Florian Muller Claudia Cerella Flavia Radogna Dicato, Mario Marc Diederich

Published in Current Medicinal Chemistry

Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research ...

Natural and Synthetic Flavonoids: Structure–Activity Relationship and Chemotherapeutic Potential for the Treatment of Le...

Menezes, José C. J. M. D. S. Orlikova, Barbora Morceau, Franck Diederich, Marc

Published in Critical Reviews in Food Science and Nutrition

Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive spectrum of pharmacological activities, including antioxidants, antitumor, anti-inflammatory, and antiviral activities. These flavonoids can also act as chemopreventive agents by their interaction with different proteins and can play a vital role in chemothera...

Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Ob...

Lee, Jin-young Orlikova, Barbora Diederich, Marc

Published in Marine Drugs

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