Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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Epipolythiodiketopiperazines from the Marine Derived Fungus Dichotomomyces cejpii with NF-κB Inhibitory Potential

Harms, Henrik Barbora Orlikova Ji, Seungwon Nesaei-mosaferan, Damun König, Gabriele Marc Diederich

Published in Marine Drugs

The Ascomycota Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. A new gliotoxin derivative, 6-acetylmonodethiogliotoxin (1) was obtained from fungal extracts. Compounds 2 and 3, methylthio-gliotoxin derivatives were formerly only known as semi-synthetic compounds and are here described as natural products. Addi...

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

Claudia Cerella Florian Muller Anthoula Gaigneaux Flavia Radogna Viry, Elodie Sébastien Chateauvieux Dicato, Mario Marc Diederich

Published in Cell Death and Disease

Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis pr...

Bispecific Antibodies: An Innovative Arsenal to Hunt, Grab and Destroy Cancer Cells

Cindy Grandjenette Dicato, Mario Marc Diederich

Published in Current Pharmaceutical Biotechnology

Targeted cellular immunotherapy with bifunctional antibodies (bsAbs) has emerged as a promising therapeutic approach for cancer over the last two decades. Progress in antibody engineering has led to the generation of many different types of antibody-derived entities that display at least two binding specificities. Most bsAbs consist of large IgG-li...

PPARγ-inactive Δ2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells

Colin-Cassin, Christelle Yao, Xiao Cerella, Claudia Chbicheb, Sarra Kuntz, Sandra Mazerbourg, Sabine Boisbrun, Michel Chapleur, Yves Diederich, Marc Flament, Stephane ...

Published in Molecular Carcinogenesis

Our aim was to better understand peroxisome proliferator-activated receptor gamma (PPARγ)-independent pathways involved in anti-cancer effects of thiazolidinediones (TZDs). We focused on Δ2-troglitazone (Δ2-TGZ), a PPARγ inactive TZD that affects breast cancer cell viability. Appearance of TUNEL positive cells, changes in mitochondrial membrane pot...

Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase meta...

Flavia Radogna Albertini, M.C. De Nicola, Milena Marc Diederich Bejarano, I. Ghibelli, Lina

Published in Mitochondrion

Extra-neurological functions of melatonin include control of the immune system and modulation of apoptosis. We previously showed that melatonin inhibits the intrinsic apoptotic pathway in leukocytes via stimulation of high affinity MT1/MT2 receptors, thereby promoting re-localization of the anti-apoptotic Bcl-2 protein to mitochondria. Here we show...

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target.

Radogna, Flavia Dicato, Mario Diederich, Marc

Published in Biochemical pharmacology

Cell death plays an essential role in the development of organs, homeostasis, and cancer. Apoptosis and programmed necrosis are two major types of cell death, characterized by different cell morphology and pathways. Accumulating evidence shows autophagy as a new alternative target to treat tumor resistance. Besides its well-known pro-survival role,...

Dual Induction of Mitochondrial Apoptosis and Senescence in Chronic Myelogenous Leukemia by Myrtucommulone A

Cindy Grandjenette Michael Schnekenburger Franck Morceau Mack, Fabienne Wiechmann, Katja Werz, Oliver Dicato, Mario Marc Diederich

Published in Anti-Cancer Agents in Medicinal Chemistry

Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve therapeutic outcome. Myrtucommulone A (MCA) is a nonprenylated acylphlor...

A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death

Bana, Emilie Sibille, Estelle Valente, Sergio Cerella, Claudia Chaimbault, Patrick Kirsch, Gilbert Dicato, Mario Diederich, Marc Bagrel, Denyse

Published in Molecular Carcinogenesis

Cell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high-grade tumors and poor prognosis. Thus, targeting CDC25 by compounds, able to inhibit their activity,...

Histone deacetylase 6 in health and disease.

Seidel, Carole Schnekenburger, Michael Dicato, Mario Diederich, Marc

Published in Epigenomics

Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein traffi...

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Cerella, Claudia Gaigneaux, Anthoula Dicato, Mario Diederich, Marc

Published in Cancer Letters

Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter ...

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