Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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Hybrid curcumin compounds: a new strategy for cancer treatment.

Teiten, Marie-Hélène Dicato, Mario Diederich, Marc

Published in Molecules (Basel, Switzerland)

Cancer is a multifactorial disease that requires treatments able to target multiple intracellular components and signaling pathways. The natural compound, curcumin, was already described as a promising anticancer agent due to its multipotent properties and huge amount of molecular targets in vitro. Its translation to the clinic is, however, limited...

P53 and Sirt1: Routes of metabolism and genome stability

Bellusci, Giovanna Ciccone, Sarah Marc Diederich Gonfloni, Stefania Iannizzotto, Valentina Maiani, Emiliano

Published in Biochemical Pharmacology

The tumor suppressor p53 is a transcription factor that regulates key processes. But, the outcomes of the p53 response go beyond its role as a nuclear transcription factor. Sirtuin (SIRT1) regulates p53 functions as transcription factor. At the same time, SIRT1 protects the genome under stress conditions. The link between p53 and SIRT1 responses is...

Modulatory roles of glycolytic enzymes in cell death

Claudia Cerella Dicato, Mario Marc Diederich

Published in Biochemical Pharmacology

Cancer cells depend on an altered energy metabolism characterized by increased rates of both glycolysis and glutaminolysis. Accordingly, corresponding key metabolic enzymes are overexpressed or hyperactivated. As a result, this newly acquired metabolic profile determines most other cancer hallmarks including resistance to cell death. Recent finding...

Metabolism 2014 – Alterations of metabolic pathways as therapeutic targets

Ji, Seungwon Kim, Jaemyun Marc Diederich Barbora Orlikova

Published in Biochemical Pharmacology

N/A

Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and micro...

Trécul, Anne Franck Morceau Anthoula Gaigneaux Michael Schnekenburger Dicato, Mario Marc Diederich

Published in Biochemical Pharmacology

Valproic acid (VPA) exhibits important pharmacological properties but has been reported to trigger side effects, notably on the hematological system. We previously reported that VPA affects hematopoietic homeostasis by inhibiting erythroid differentiation and promoting myeloid and megakaryocyte differentiation. Here, we analyzed the effect of VPA o...

Plant-derived epigenetic modulators for cancer treatment and prevention

Michael Schnekenburger Dicato, Mario Marc Diederich

Published in Biotechnology Advances

Carcinogenesis is a complex and multistep process that involves the accumulation of successive transformational events driven by genetic mutations and epigenetic alterations that affect major cellular processes and pathways such as proliferation, differentiation, invasion and survival. Massive deregulation of all components of the epigenetic machin...

From Nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment

Cerella, Claudia Teiten, Marie-Hélène Radogna, Flavia Dicato, Mario Diederich, Marc

Published in Biotechnology Advances

•act as activators of specific apoptotic commitments•modulate the stress balance and equilibrate between death and survival•target prosurvival and pro-death pathways•inhibit NF-kB-regulated survival genes

Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones.

Kuntz, Sandra Mazerbourg, Sabine Boisbrun, Michel Cerella, Claudia Diederich, Marc Grillier-Vuissoz, Isabelle Flament, Stéphane

The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ that were developed to treat type II diabetes. These compounds also disp...

Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and micro...

Trécul, Anne Morceau, Franck Gaigneaux, Anthoula Schnekenburger, Michael Dicato, Mario Diederich, Marc

Published in Biochemical pharmacology

Valproic acid (VPA) exhibits important pharmacological properties but has been reported to trigger side effects, notably on the hematological system. We previously reported that VPA affects hematopoietic homeostasis by inhibiting erythroid differentiation and promoting myeloid and megakaryocyte differentiation. Here, we analyzed the effect of VPA o...

Synthesis and bioactivity of novel amino-pyrazolopyridines

Chaouni, Wafaa Schumacher, Marc Aadil, Mina Kirsch, Gilbert Diederich, Marc Orlikova, Barbora

Published in European Journal of Medicinal Chemistry

Here we describe the synthesis and biological activity of novel amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential. α-Methylene ketones were used as a starting point for synthesis of amino-pyrazolopyridine 3. The alkylidene malononitriles 1 were obtained by the Knoevenagel reaction of ketones with malononitriles. Vilsmeier-Haack re...

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