Published in International Journal of Cell Biology
Hindawi Publishing Corporation International Journal of Cell Biology Volume 2013, Article ID 293201, 2 pages http://dx.doi.org/10.1155/2013/293201 Editorial Metabolism and Cancer: Old and New Players Claudia Cerella,1 Carine Michiels,2 Roderick H. Dashwood,3 Young-Joon Surh,4 and Marc Diederich4 1 Laboratoire de Biologie Mole´culaire et Cellulaire ...
Published in The Analyst
The multiresistant phenotype is an important problem in cancer chemotherapy. It is characterized by cell resistance to multiple and structurally unrelated drugs. We have shown previously that K562 multiresistant leukemia cells could be differentiated from their sensitive counterparts (wild-type K562 cells) on the basis of their infrared spectrum. I...
Published in Frontiers in Oncology
Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occu...
Published in Journal of Medicinal Chemistry
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass s...
Published in Bioorganic & Medicinal Chemistry
Altersolanol A, a natural product from the endophytic fungus Stemphylium globuliferum isolated from the medicinal plant Mentha pulegium (Lamiaceae) growing in Morocco, shows cytotoxic, cytostatic, anti-inflammatory and anti-migrative activity against human chronic myeloid K562 leukemia and A549 lung cancer cells in a dose dependent manner without a...
Published in Fitoterapia
Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G.macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from this extracts afforded six compou...
Published in Cellular and Molecular Life Sciences
Glucocorticoids (GCs) block inflammation via interference of the liganded glucocorticoid receptor (GR) with the activity of pro-inflammatory transcription factors NF-κB and AP-1, a mechanism known as transrepression. This mechanism is believed to involve the activity of GR monomers. Here, we explored how the GR monomer-favoring Compound A (CpdA) af...
Published in Molecular Nutrition & Food Research
Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as a promising source of new epigenetically active...
Published in Investigational New Drugs
Cardiac glycosides have a long history in the treatment of cardiac disease. However, several preclinical studies as well as two phase I studies have shown that cardenolides may also possess anticancer effects. The mechanisms of these anticancer effects may include intracellular decrease of K(+) and increase of Na(+) and Ca(2+); intracellular acidif...
Published in Mitochondrion
Cardiac glycosides (CGs) are compounds used for the treatment of cardiac failure which also display strong anti-cancer activity inducing impairment of cell proliferation or activation of cell death whether by apoptosis or autophagy. Despite the fact that the sodium/potassium (Na(+)/K(+))-ATPase is a well-known target of CGs, its involvement in the ...
