Laboratoire de Biologie Moléculaire et Cellulaire du Cancer

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Dual Induction of Mitochondrial Apoptosis and Senescence in Chronic Myelogenous Leukemia by Myrtucommulone A

Cindy Grandjenette Michael Schnekenburger Franck Morceau Mack, Fabienne Wiechmann, Katja Werz, Oliver Dicato, Mario Marc Diederich

Published in Anti-Cancer Agents in Medicinal Chemistry

Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve therapeutic outcome. Myrtucommulone A (MCA) is a nonprenylated acylphlor...

Chemical Properties and Mechanisms Determining the Anti-Cancer Action of Garlic-Derived Organic Sulfur Compounds

Claudia Cerella Dicato, Mario Jacob, Claus Marc Diederich

Published in Anti-Cancer Agents in Medicinal Chemistry

Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents. Garlic, which has long been used as a medicinal plant in different cultures due to its multiple beneficial effec...

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