Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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In vitro characterisation of the anti-intravasative properties of the marine product heteronemin

Kopf, Sabine Viola, Katharina Atanas G. Atanasov Jarukamjorn, Kanokwan Rarova, Lucie Kretschy, Nicole Teichmann, Mathias Vonach, Caroline Saiko, Philipp Giessrigl, Benedikt ...

Published in Archives of Toxicology

Metastases destroy the function of infested organs and are the main reason of cancer-related mortality. Heteronemin, a natural product derived from a marine sponge, was tested in vitro regarding its properties to prevent tumour cell intravasation through the lymph-endothelial barrier. In three-dimensional (3D) cell cultures consisting of MCF-7 brea...

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