Borde-Chiché, Patricia Marc Diederich Franck Morceau Puga, Alvaro Wellman, Maria Dicato, Mario
Published in
Biochemical Pharmacology
To study the relationship between methylation and the transcriptional activity of the minimal promoter of the glutathione S-transferase GSTP1 gene encoding glutathione S-transferase P1-1, GSTP1 mRNA levels as well as basal promoter activity were compared in human leukemia cell lines. The K562 erythroleukemia cell line presented a strong GSTP1 promo...
Published in
Biochemical Pharmacology
Trécul, Anne Franck Morceau Anthoula Gaigneaux Michael Schnekenburger Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Valproic acid (VPA) exhibits important pharmacological properties but has been reported to trigger side effects, notably on the hematological system. We previously reported that VPA affects hematopoietic homeostasis by inhibiting erythroid differentiation and promoting myeloid and megakaryocyte differentiation. Here, we analyzed the effect of VPA o...
Karius, Tommy Michael Schnekenburger Ghelfi, Jenny Walter, Jörn Dicato, Mario Marc Diederich
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Biochemical Pharmacology
Glutathione-S-transferase P1 (GSTP1) gene is commonly silenced by CpG island promoter hypermethylation in prostate, breast, and liver cancers. However, mechanisms leading to GSTP1 repression by promoter hypermethylation in leukemia and its relationship with pathological alterations of the chromatin structure remain poorly understood. A panel of leu...
Marc Diederich Florian Muller Claudia Cerella
Published in
Biochemical Pharmacology
Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase (NKA). Pharmacologically, they represent a well-known generation of drugs for treating cardiovascular problems, thus allowing the investigation of potential dose-depende...
Sobolewski, Cyril Viry, Elodie Legrand, Noémie Florian Muller Franck Morceau Marc Diederich
Published in
Biochemical Pharmacology
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Richard Sawadogo, Wamtinga Schumacher, Marc Teiten, Marie-Hélène Dicato, Mario Diederich, Marc
Published in
Biochemical Pharmacology
Traditional pharmacopeia is strongly involved in the continuous search for the well being of African populations. The World Health Organization (WHO) estimates that 80% of the population of developing countries relies on traditional medicine for their primary care needs. Medicinal plants are the major resource of this folk medicine where several sp...
Published in
Biochemical Pharmacology
Schumacher, Marc Claudia Cerella Eifes, Serge Sébastien Chateauvieux Franck Morceau Jaspars, Marcel Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
In this study, we investigated the biological effects of heteronemin, a marine sesterterpene isolated from the sponge Hyrtios sp. on chronic myelogenous leukemia cells. To gain further insight into the molecular mechanisms triggered by this compound, we initially performed DNA microarray profiling and determined which genes respond to heteronemin s...
Buck, Isabelle Franck Morceau Grigorakaki, Christina Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Erythropoiesis is considered as a multistep and tightly regulated process under the control of a series of cytokines including erythropoietin (Epo). Epo activates specific signaling pathways and leads to activation of key transcription factors such as GATA-1, in order to ensure erythroid differentiation. Deregulation leads to a decreased number of ...
