Duvoix, Annelyse Delhalle, Sylvie Blasius, Romain Michael Schnekenburger Franck Morceau Fougère, Marjorie Henry, Estelle Galteau, Marie-Madeleine Dicato, Mario Marc Diederich
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Published in
Biochemical Pharmacology
Glutathione S-transferase P1-1 (GSTP1-1) is a phase II drug metabolism enzyme implicated in carcinogenesis and development of resistance to anti-cancer drugs. It was previously shown that both activating protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB) are involved in its regulation. In the present study we examined the inhibitory effect of s...
Franck Morceau Duvoix, A. Delhalle, S. Schnekenburger, M. Dicato, Marc Marc Diederich
Published in
Biochemical Pharmacology
Glutathione S-transferases (GSTs) play an important role in the protection of cells against xenobiotics and lipid hydroperoxides generated by oxidative stress. In human, the GSTP1-1 expression is commonly increased in many tumors and involved in the development of antineoplastic drug resistance. Reactive oxygen species are released at inflammation ...
Tom Juncker Claudia Cerella Marie-Hélène Teiten Franck Morceau Marc Schumacher Jenny Ghelfi François Gaascht Michael Schnekenburger Estelle Henry Mario Dicato
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Published in
Biochemical Pharmacology
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a hemi-synthetic cardenolide belonging to the cardiac steroid glycoside family. Here, we report that, at low nanomolar concentrations, UNBS1450 induces apoptotic cell dea...
Bellusci, Giovanna Ciccone, Sarah Marc Diederich Gonfloni, Stefania Iannizzotto, Valentina Maiani, Emiliano
Published in
Biochemical Pharmacology
The tumor suppressor p53 is a transcription factor that regulates key processes. But, the outcomes of the p53 response go beyond its role as a nuclear transcription factor. Sirtuin (SIRT1) regulates p53 functions as transcription factor. At the same time, SIRT1 protects the genome under stress conditions. The link between p53 and SIRT1 responses is...
Courtay, Céline Oster, Thierry Michelet, France Visvikis, Athanase Marc Diederich Wellman, Maria Siest, Gérard
Published in
Biochemical Pharmacology
γ-Glutamyltransferase (GGT, EC 2.3.2.2) is an enzyme involved in glutathione metabolism and drug and xenobiotic detoxification. Using human hepatoma Hep G2 GGT cDNA as probe, we isolated a cDNA from a human pancreatic cDNA library. Analysis of the nucleotide sequences revealed a 2244-bp insert that includes an open reading frame of 1710 bp, encodin...
Ghibelli, Lina Marc Diederich
Published in
Biochemical Pharmacology
Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocyt...
Chateauvieux, Stéphane Grigorakaki, C. Franck Morceau Dicato, Marc Marc Diederich
Published in
Biochemical Pharmacology
Erythropoietin (EPO) is a glycoprotein that is mainly produced in the adult kidney, and it was initially highlighted for its action on the hematopoietic system. Moreover, EPO is also expressed in several non-hematopoietic tissues, where it plays a role in the protection from apoptosis and inflammation due to hypoxia, toxicity or injury. These prote...
Blasius, Romain Reuter, Simone Henry, Estelle Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Signal transducers and activators of transcription (STATs) play important roles in numerous cellular events as for example differentiation, inflammation or immune response. Furthermore, constitutive STAT activation can be observed in a high number of tumors. In our hands, curcumin treatment induced a decrease of nuclear STAT3, -5a and -5b, without ...
Seidel, Carole Marc Diederich Mazumder, Aloran Kirsch, Gilbert Dicato, Mario Michael Schnekenburger Marie-Hélène Teiten
Published in
Biochemical Pharmacology
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including α-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
Barbora Orlikova Tasdemir, Deniz Golais, Frantisek Dicato, Mario Marc Diederich
Published in
Biochemical Pharmacology
Chalcones are aromatic ketones, known to exhibit anti-microbial, anti-inflammatory and anti-cancer activities. The aim of this study was to investigate the anti-inflammatory and anti-cancer activity of 4'-hydroxychalcone. Here, we report that 4'-hydroxychalcone inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner. To investigat...
