Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives
Published in Biochemical Pharmacology
Oxidation-dependent maturation and survival of explanted blood monocytes via Bcl-2 up-regulation
Published in Biochemical Pharmacology
Monocytes isolated and cultured according to standard procedures from the blood of 22 healthy donors display an activation process, monitored as adhesion and increased exposure of CD11. Starting from very early time points, monocytes undergo a deep redox modulation, i.e., they increase reactive oxygen species (ROS) formation and decrease glutathion...
MicroRNAs in cancer management and their modulation by dietary agents
Published in Biochemical Pharmacology
MicroRNAs (miRNAs) represent a class of small (21–23 nucleotides) non-coding RNAs that emerged as key post-transcriptional gene regulators, implicated in numerous physiological and pathological processes. Currently, a main focus of miRNA research is related to the roles of miRNAs in cancer development. The biogenesis and modes of action of miRNAs h...
Tumor necrosis factor alpha-mediated inhibition of erythropoiesis involves GATA-1/GATA-2 balance impairment and PU.1 ove...
Published in Biochemical Pharmacology
Corrigendum to “Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibit...
Published in Biochemical Pharmacology
In this study, we investigated the biological effects of heteronemin, a marine sesterterpene isolated from the sponge Hyrtios sp. on chronic myelogenous leukemia cells. To gain further insight into the molecular mechanisms triggered by this compound, we initially performed DNA microarray profiling and determined which genes respond to heteronemin s...
Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 le...
Published in Biochemical Pharmacology
Tumor necrosis factor α inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pa...
Published in Biochemical Pharmacology
Tumor necrosis factor α induces γ-glutamyltransferase expression via nuclear factor-κB in cooperation with Sp1
...Published in Biochemical Pharmacology
γ-Glutamyltransferase (GGT) cleaves the γ-glutamyl moiety of glutathione (GSH), an endogenous antioxidant, and is involved in mercapturic acid metabolism and in cancer drug resistance when overexpressed. Moreover, GGT converts leukotriene (LT) C4 into LTD4 implicated in various inflammatory pathologies. So far the effect of inflammatory stimuli on ...
Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions
Published in Biochemical Pharmacology
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including cancer. Here we summ...
Linking anemia to inflammation and cancer: The crucial role of TNFα
Published in Biochemical Pharmacology
