Linking anemia to inflammation and cancer: The crucial role of TNFα
Published in Biochemical Pharmacology
Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myel...
Published in Biochemical Pharmacology
In addition to its demethylating properties, 2'-deoxy-5-azacytidine (DAC) induces cell cycle arrest, differentiation, cell sensitization to chemotherapy, and cell death. However, the mechanisms by which DAC induces antiproliferation via these processes and how they are interconnected remain unclear. In this study, we found that a clinically relevan...
The inhibition of TNF-α-induced NF-κB activation by marine natural products
...Published in Biochemical Pharmacology
The deregulated activation of NF-kappaB is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappaB inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and ...
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells
Published in Biochemical Pharmacology
Apoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. As one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. Curcumin, a natural compound isolated from the plant Curcuma long...
Inhibition of TNFα-induced activation of nuclear factor κB by kava (Piper methysticum) derivatives
Published in Biochemical Pharmacology
The inducible transcription factor nuclear factor kappaB (NF-kappaB) plays a central role in the regulation of immune, inflammatory and carcinogenic responses. While normal activation of NF-kappaB is required for cell survival and immunity, its deregulated expression is a characteristic of inflammatory and infectious diseases. In this study, we inv...
