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Expression of glutathione S-transferase P1-1 in differentiating K562: role of GATA-1

Published in Biochemical and Biophysical Research Communications

Glutathione S-transferase P1-1 (GSTP1-1) conjugates glutathione to electrophilic compounds and its expression is correlated to chemotherapeutic drug resistance. Results show that GSTP1-1 mRNA as well as protein expressions are increased during Aclarubicin (Acla)- and Doxorubicin (Dox)-induced erythroid differentiation of human K562 cells. In contra...

Expression of glutathione S-transferase P1-1 in differentiating K562: role of GATA-1

Published in Biochemical and Biophysical Research Communications

Phorbol ester regulation of the human γ-glutamyltransferase gene promoter

Published in Biochemical and Biophysical Research Communications

In the present study the molecular mechanisms underlying tetradecanoylphorbol-13-acetate (TPA) mediated regulation of the human gamma-glutamyltransferase (GGT) gene were examined. TPA challenge of HeLa cells resulted in an increase of GGT mRNA and enzyme activity. Deletion analysis of the promoter revealed that the -348 to +60 fragment was able to ...