Marie-Hélène Teiten Mack, Fabienne Debbab, Abdessamad Aly, Amal H. Dicato, Mario Proksch, Peter Marc Diederich
Published in
Bioorganic & Medicinal Chemistry
Altersolanol A, a natural product from the endophytic fungus Stemphylium globuliferum isolated from the medicinal plant Mentha pulegium (Lamiaceae) growing in Morocco, shows cytotoxic, cytostatic, anti-inflammatory and anti-migrative activity against human chronic myeloid K562 leukemia and A549 lung cancer cells in a dose dependent manner without a...
Talhi, Oualid Michael Schnekenburger Panning, Jana G.C. Pinto, Diana Fernandes, José A. Almeida Paz, Filipe A. Jacob, Claus Marc Diederich M.S. Silva, Artur
Published in
Bioorganic & Medicinal Chemistry
Synthesis of the bis-4-hydroxycoumarin-type compound, 3,3'-[3-(2-hydroxyphenyl)-3-oxopropane-1,1-diyl]bis(4-hydroxy-2H-chromen-2-one), was performed by two alternative pathways, either involving a basic organocatalyzed 1,4-conjugate addition tandem reaction of 4-hydroxycoumarin on chromone-3-carboxylic acid, or a double condensation of 4-hydroxycou...
Yadav, Babasaheb Taurin, Sebastien Rosengren, Rhonda J. Schumacher, Marc Marc Diederich Somers-Edgar, Tiffany J. Larsen, Lesley
Published in
Bioorganic & Medicinal Chemistry
A series of 18 heterocyclic cyclohexanone analogues of curcumin have been synthesised and screened for their activity in both adherent and non-adherent cancer cell models. Cytotoxicity towards MBA-MB-231 breast cancer cells, as well as ability to inhibit NF-kappaB transactivation in non-adherent K562 leukemia cells were investigated. Three of these...
Aly, Amal H. Debbab, Abdessamad Clements, Carol Edrada-Ebel, Ruangelie Barbora Orlikova Marc Diederich Wray, Victor Lin, Wenhan Proksch, Peter
Published in
Bioorganic & Medicinal Chemistry
Chemical investigation of the endophytic fungus Penicillium sp. isolated from Limonium tubiflorum growing in Egypt afforded four new compounds of polyketide origin, including two macrolides, penilactone (1) and 10,11-epoxycurvularin (2), a dianthrone, neobulgarone G (7), and a sulfinylcoumarin, sulfimarin (14), along with twelve known metabolites (...
