Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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Expression of glutathione S-transferase P1-1 in leukemic cells is regulated by inducible AP-1 binding

Duvoix, Annelyse Michael Schnekenburger Delhalle, Sylvie Blasius, Romain Borde-Chiché, Patricia Franck Morceau Dicato, Mario Marc Diederich

Published in Cancer Letters

Glutathione S-transferases (GST) are involved in cellular protection against xenobiotics, oxidative stress as well as in resistance against chemotherapeutic compounds such as doxorubicin. Levels of human placental type GSTP1-1 are known to be increased in many tumors and hematopoietic diseases. In this work, we compare transcriptional mechanisms in...

Chemopreventive and therapeutic effects of curcumin

Duvoix, Annelyse Blasius, Romain Delhalle, Sylvie Michael Schnekenburger Franck Morceau Henry, Estelle Dicato, Mario Marc Diederich

Published in Cancer Letters

Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. Curcumin is also described as an anti-tumoral...

General method of synthesis for metal nanoparticles

Panigrahi, Sudipa Kundu, Subrata Ghosh, Sujit Nath, Sudip Pal, Tarasankar

Published in Journal of Nanoparticle Research

Sugar-assisted stable monometallic nanoparticles were synthesized by wet chemical method following a general scheme. Judicious manipulation of the reducing capabilities of different sugars has shown to have a bearing on the particle size that corroborates the shift of the absorbance peak positions and TEM analysis. Evaporation of the precursor solu...

Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases.

Seidel, Carole Schnekenburger, Michael Dicato, Mario Diederich, Marc

Published in Cancer letters

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate cellular processes by modifying the acetylation status of many proteins. Pathologically altered HDAC activity contributes to cancer development and thus characterization of novel acetylation modulators is important for future anti-cancer therapies. In this study, we identif...

Epigenetic modulators from “The Big Blue”: A treasure to fight against cancer

Marc Diederich Dicato, Mario

Published in Cancer Letters

Cancer remains a major public health problem in our society. The development of potent novel anti-cancer drugs selective for tumor cells is therefore still required. Deregulation of the epigenetic machinery including DNA methylation, histone modifications and non-coding RNAs is a hallmark of cancer, which provides potential new therapeutic targets....

Induction of heat shock response by curcumin in human leukemia cells

Marie-Hélène Teiten Reuter, Simone Schmucker, Stéphane Dicato, Mario Marc Diederich

Published in Cancer Letters

Heat shock response is an adaptive response, which helps the cells to regulate their physiological homeostasis under stress. Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 pr...

Tumor necrosis factor alpha inhibits aclacinomycin A-induced erythroid differentiation of K562 cells via GATA-1

Michael Schnekenburger Blasius, Romain Buck, Isabelle Dicato, Mario Marc Diederich Franck Morceau

Published in Cancer Letters

Up-regulation of tumor necrosis factor alpha (TNFalpha) is linked to solid tumors as well as to hematologic disorders including different forms of anemia and multiple myeloma. This cytokine was shown to contribute to inhibition of erythroid maturation mechanisms which are characterized by the expression of specific genes regulated by GATA-1 and NF-...

Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c...

Esma Yagdi Aloran Mazumder Jin-Young Lee Anthoula Gaigneaux Flavia Radogna Muhammad Jawad Nasim Christo Christov Claus Jacob Kyu-Won Kim Mario Dicato ...

Published in Cancer Letters

Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...

Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr–Abl oncokinase expression in correlation with STAT3/STAT5...

Trécul, Anne Franck Morceau Anthoula Gaigneaux Marion Orsini Sébastien Chateauvieux Cindy Grandjenette Dicato, Mario Marc Diederich

Published in Cancer Letters

Constitutive activity of kinases has been reported in many types of cancers, so that inhibition of "onco-kinases" became a validated anti-cancer strategy. We found that the polyphenol 13c, a tri-vanillate derivative, inhibited kinase phosphorylation in leukemia cells. P-JAK2, P-Src and P-PI3Kp85 inhibition occurred independently of phosphatase invo...

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Cerella, Claudia Gaigneaux, Anthoula Dicato, Mario Diederich, Marc

Published in Cancer Letters

Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter ...

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