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Laboratoire de Biologie Moléculaire et Cellulaire du Cancer

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Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases.

Seidel, Carole Schnekenburger, Michael Dicato, Mario Diederich, Marc

Published in Cancer letters

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate cellular processes by modifying the acetylation status of many proteins. Pathologically altered HDAC activity contributes to cancer development and thus characterization of novel acetylation modulators is important for future anti-cancer therapies. In this study, we identif...

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Cerella, Claudia Gaigneaux, Anthoula Dicato, Mario Diederich, Marc

Published in Cancer Letters

Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter ...

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