Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1
...Published in Cellular and Molecular Life Sciences
Glucocorticoids (GCs) block inflammation via interference of the liganded glucocorticoid receptor (GR) with the activity of pro-inflammatory transcription factors NF-κB and AP-1, a mechanism known as transrepression. This mechanism is believed to involve the activity of GR monomers. Here, we explored how the GR monomer-favoring Compound A (CpdA) af...
