Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/M... PDF available through Get Fulltext Research

Lernoux, Manon Schnekenburger, Michael Losson, Hélène Vermeulen, Koen Hahn, Hyunggu Gérard, Déborah Lee, Jin-Young Mazumder, Aloran Ahamed, Muneer Christov, Christo ...

Published in Clinical Epigenetics

BackgroundChronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnormal constitutive tyrosine kinase activity, therapies using tyrosine kinase inhibitors (TKis) such as imatinib represent a major break...

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