Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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Bispecific Antibodies: An Innovative Arsenal to Hunt, Grab and Destroy Cancer Cells

Cindy Grandjenette Dicato, Mario Marc Diederich

Published in Current Pharmaceutical Biotechnology

Targeted cellular immunotherapy with bifunctional antibodies (bsAbs) has emerged as a promising therapeutic approach for cancer over the last two decades. Progress in antibody engineering has led to the generation of many different types of antibody-derived entities that display at least two binding specificities. Most bsAbs consist of large IgG-li...

Targeting the Wingless Signaling Pathway with Natural Compounds as Chemopreventive or Chemotherapeutic Agents

Marie-Hélène Teiten Francois Gaascht Dicato, Mario Marc Diederich

Published in Current Pharmaceutical Biotechnology

The aberrant activation of the wingless (Wnt) signaling pathway is a key element involved in carcinogenesis as Wnt regulates a variety of cellular processes including proliferation, differentiation, survival, apoptosis and cell motility. Upon Wnt receptor activation, the canonical "Wnt/beta-catenin" as well as the non canonical "Wnt/planar cell pol...

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