Michael Schnekenburger Marc Diederich
Published in
Current Topics in Medicinal Chemistry
A majority of cancers display alterations in epigenetic mechanisms, such as aberrant DNA methylation at CpG islands (CGIs). This local hypermethy-lation of CGIs is associated with gene silencing leading to loss of tumor sup-pressor gene (TSG) functions that are critical for the control of tumor devel-opment. Concomitantly, global genomic hypomethyl...
Michael Schnekenburger Cristina Florean Dicato, Mario Marc Diederich
Published in
Current Topics in Medicinal Chemistry
Despite considerable scientific progress, the burden of cancer in our society remains a major public health problem. Tumorigenesis is recognized as a complex and multistep process that involves the accumulation of successive transformational events with multi-factorial etiology. Nevertheless, such events result in the acquisition of key hallmark ch...
Miglena Koprinarova Michael Schnekenburger Marc Diederich
Published in
Current Topics in Medicinal Chemistry
Core histone acetylation is a key prerequisite for chromatin decondensation and plays a pivotal role in regulation of chromatin structure, function and dynamics. The addition of acetyl groups disturbs histone/DNA interactions in the nucleosome and alters histone/histone interactions in the same or adjacent nucleosomes. Acetyl groups can also provid...
Michael Schnekenburger Cristina Florean Cindy Grandjenette Marc Diederich
Published in
Current Topics in Medicinal Chemistry
Folmer, Florence Dicato, Mario Marc Diederich
Published in
Current Topics in Medicinal Chemistry
TNF-α was discovered more then 20 years ago as a cytokine implicated in a wide range of cell signaling pathways, many of which are known to lead to the activation of genes involved in inflammation and carcinogenesis. TNF-α is involved in the pathogenesis of many diseases, including Crohn's disease, diabetes, septic shock, tumorigenesis, rheumatoid ...
