Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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Methylenedioxy flavonoids: Assessment of cytotoxic and anti-cancer potential in human leukemia cells

Barbora Orlikova C.J.M.D.S. Menezes, José Ji, Seungwon Kamat, Shrivallabh P. A.S. Cavaleiro, José Marc Diederich

Published in European Journal of Medicinal Chemistry

A new series of chalcones, flavanones and flavones with methylenedioxy group at the 3',4' position in chalcone, 7,8 position in flavanones and flavones with mono-, di- and trimethoxy groups in the benzaldehyde ring have been assessed for their effect on proliferation, cytotoxic potential and apoptosis in human leukemia cells. Among the tested compo...

Synthesis and bioactivity of novel amino-pyrazolopyridines

Chaouni, Wafaa Schumacher, Marc Aadil, Mina Kirsch, Gilbert Marc Diederich Barbora Orlikova

Published in European Journal of Medicinal Chemistry

Here we describe the synthesis and biological activity of novel amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential. α-Methylene ketones were used as a starting point for synthesis of amino-pyrazolopyridine 3. The alkylidene malononitriles 1 were obtained by the Knoevenagel reaction of ketones with malononitriles. Vilsmeier-Haack re...

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