Laboratoire de Biologie Moléculaire et Cellulaire du Cancer
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Localization of a regulatory region on the 5′-untranslated region of human hepatoma HepG2 γ-glutamyltransferase mRNA and...

Marc Diederich Wellman, Maria Siest, Gérard

Published in FEBS Letters

We are reporting the functional analysis of the 5'-untranslated region (5'UTR) of human hepatoma HepG2 gamma-glutamyltransferase (GGT) mRNA. Transient expression of hybrid GGT-luciferase reporter gene mutants in HepG2 shows that this 5'UTR acts as a tissue-specific translational enhancer. A domain of 173 bases containing a steroid hormone response ...

The 5' untranslated region of the human γ-glutamyl transferase mRNA contains a tissue-specific active translational enha...

Marc Diederich Wellman, Maria Visvikis, Athanase Puga, Alvaro Siest, Gérard

Published in FEBS Letters

We report the functional and structural analysis of the 5' untranslated region (5'UTR) of human hepatoma HepG2 gamma-glutamyltransferase (GGT) mRNA. Transient expression of a hybrid GGT-luciferase gene in HepG2, MIA-Pa-Ca-2 and MG 63 cell lines shows that this 5'UTR acts as a tissue-specific translational enhancer. Evidence for transcripts with mul...

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