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Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis

Clocchiatti, Andrea Cristina Florean Brancolini, Claudio

Published in Journal of Cellular and Molecular Medicine

Histone deacetylases (HDACs) are important regulators of gene expression. Specific structural features and distinct regulative mechanisms rationalize the separation of the 18 different human HDACs into four classes. The class II comprises a heterogeneous group of nuclear and cytosolic HDACs involved in the regulation of several cellular functions, ...

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

Brunello, Lucia Zampese, Enrico Cristina Florean Pozzan, Tullio Pizzo, Paola Fasolato, Cristina

Published in Journal of Cellular and Molecular Medicine

We have previously shown that familial Alzheimer’s disease mutants of presenilin-2 (PS2) and, to a lesser extent, of presenilin-1 (PS1) lower the Ca2+ concentration of intracellular stores. We here examined the mechanism by which wild-type and mutant PS2 affect store Ca2+ handling. By using HeLa, SH-SY5Y and MEFs as model cells, and recombinant aeq...

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Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake