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Flavonoid glycosides from Olax mannii: Structure elucidation and effect on the nuclear factor kappa B pathway

B.C. Okoye, Festus Richard Sawadogo, Wamtinga Sendker, Jandirk Aly, Amal H. Quandt, Bettina Wray, Victor Hensel, Andreas Esimone, Charles O. Debbab, Abdessamad Marc Diederich ...

Published in Journal of Ethnopharmacology

Ethnopharmacological relevance: Olax mannii Oliv. (Olacaceae) is among the many medicinal plants used in Nigeria for the ethnomedicinal management of both cancer and inflammation. Such plants represent potential sources of innovative therapeutic agents for the treatment of cancer and other malignant disorders. While the majority of medicinal plants...

The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies

Sobolewski, Cyril Cerella, Claudia Dicato, Mario Ghibelli, Lina Diederich, Marc

Published in International Journal of Cell Biology

It is well admitted that the link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways, which act during the different steps of tumorigenesis. The cyclooxygenases (COXs) are a family of enzymes, which catalyze the rate-limiting step of prostaglandin biosynthesis. This family contains three members: ubiqu...

Inhibitory effect of St. John׳s Wort oil macerates on TNFα-induced NF-κB activation and their fatty acid composition

Erdogan Orhan, Ilkay Kartal, Murat Rifat Gülpinar, Ali Yetkin, Gülin Barbora Orlikova Marc Diederich Tasdemir, Deniz

Published in Journal of Ethnopharmacology

The oil macerates of Hypericum perforatum L. (St. John's Wort=SJW) has a long history of medicinal use and SJW has been used in traditional medicine both orally and topically for centuries worldwide mainly for wound healing, ulcer and inflammation.

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