Doering, Mandy Ba, Lalla A. Lilienthal, Nils Nicco, Carole Scherer, Christiane Abbas, Muhammad Ali Peer Zada, Abdul Coriat, Romain Burkholz, Torsten Wessjohann, Ludger
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Published in
Journal of Medicinal Chemistry
in Oct 14, 2010
Many tumor cells exhibit a disturbed intracellular redox state resulting in higher levels of reactive oxygen species (ROS). As these contribute to tumor initiation and sustenance, catalytic redox agents combining significant activity with substrate specificity promise high activity and selectivity against oxidatively stressed malignant cells. We de...
Schnekenburger, Michael Goffin, Eric Lee, Jin-Young Young Jang, Jun Mazumder, Aloran Ji, Seungwon Rogister, Bernard Bouider, Nafila Lefranc, Florence Miklos, Walter
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Published in
Journal of Medicinal Chemistry
in May 09, 2017
A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. Based on computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyano...
Valente, Sergio Liu, Yiwei Schnekenburger, Michael Zwergel, Clemens Cosconati, Sandro Gros, Christina Tardugno, Maria Labella, Donatella Florean, Cristina Minden, Steven
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Published in
Journal of Medicinal Chemistry
in Feb 13, 2014
Ebrahim, Weaam Aly, Amal H. Wray, Victor Mándi, Attila Teiten, Marie-Hélène Gaascht, François Orlikova, Barbora Kassack, Matthias U. Lin, Wenhan Diederich, Marc
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Published in
Journal of Medicinal Chemistry
in Aug 21, 2013
Two new metabolites, embellicines A and B (1 and 2), were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of extensive one- and two-dimensional NMR spectroscopy as well as by high-resolution mass s...