Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription
Published in Journal of Neurochemistry
We investigated whether the CYP46A1 gene, a neuronal-specific cytochrome P450, responsible for the majority of brain cholesterol turnover, is subject to transcriptional modulation through modifications in histone acetylation. We demonstrated that inhibition of histone deacetylase activity by trichostatin A (TSA), valproic acid and sodium butyrate c...
