Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2
Published in Journal of Pineal Research
We have recently shown that melatonin antagonizes damage-induced apoptosis by interaction with the MT-1/MT-2 plasma membrane receptors. Here, we show that melatonin interferes with the intrinsic pathway of apoptosis at the mitochondrial level. In response to an apoptogenic stimulus, melatonin allows mitochondrial translocation of the pro-apoptotic ...
