Anthracyclines as Tumor Cell Differentiating Agents: Effects on the Regulation of Erythroid Gene Expression
Published in Leukemia & Lymphoma
Tumor cells, and particularly leukemic cells, can be considered as maturation-arrested cells which have escaped some normal control and continue to proliferate. This maturation arrest can be reversed by differentiation agents such as antitumor drugs currently used in conventional cytotoxic chemotherapy. In this respect, anthracyclines have been sho...
