Laboratoire de Biologie Moléculaire et Cellulaire du Cancer

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Phorbol ester responsiveness of the glutathione S-transferase P1 gene promoter involves an inducible c-jun binding in hu...

Borde-Chiché, Patricia Franck Morceau Wellman, Maria Dicato, Mario Marc Diederich

Published in Leukemia Research

Overexpression of the glutathione S-transferase P1 (GSTP1) gene is related to drug resistance in human cancer cells. However, the mechanisms of the transcriptional activation of this gene remain unclear. In this study, we examined the molecular mechanisms underlying phorbol ester mediated gene regulation using human K562 leukemia cells as a model. ...

Transcriptional and post-transcriptional regulation of glutathione S-transferase P1 expression during butyric acid-induc...

Michael Schnekenburger Franck Morceau Henry, Estelle Blasius, Romain Dicato, Mario Trentesaux, Chantal Marc Diederich

Published in Leukemia Research

Over-expression of glutathione S-transferase P1 is related to chemotherapeutic drug resistance as well as to differentiation of human erythroleukemia cells. In opposition to previously described differentiating inducers which enhance the GST-resistance phenotype, time- and concentration-dependent activation of both erythroid and megakaryocytic diff...

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