Search on Laboratoire de Biologie Moléculaire et Cellulaire d...

Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase meta...

Flavia Radogna Albertini, M.C. De Nicola, Milena Marc Diederich Bejarano, I. Ghibelli, Lina

Extra-neurological functions of melatonin include control of the immune system and modulation of apoptosis. We previously showed that melatonin inhibits the intrinsic apoptotic pathway in leukocytes via stimulation of high affinity MT1/MT2 receptors, thereby promoting re-localization of the anti-apoptotic Bcl-2 protein to mitochondria. Here we show...

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

Dicato, Mario Claudia Cerella Marc Diederich

Published in Mitochondrion

Cardiac glycosides (CGs) are compounds used for the treatment of cardiac failure which also display strong anti-cancer activity inducing impairment of cell proliferation or activation of cell death whether by apoptosis or autophagy. Despite the fact that the sodium/potassium (Na(+)/K(+))-ATPase is a well-known target of CGs, its involvement in the ...

Multistep and multitask Bax activation

Ghibelli, Lina Marc Diederich

Published in Mitochondrion

Bax is a pro-apoptotic protein allowing apoptosis to occur through the intrinsic, damage-induced pathway, and amplifying that one occurring via the extrinsic, receptor mediated pathway. Bax is present in viable cells and activated by pro-apoptotic stimuli. Activation implies structural changes, consisting of exposure of the N terminus and hydrophob...

Publication search

Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase meta...

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

Multistep and multitask Bax activation