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Pro-Apoptotic and Immunostimulatory Tetrahydroxanthone Dimers from the Endophytic Fungus Phomopsis longicolla

Rönsberg, David Debbab, Abdessamad Mándi, Attila Vasylyeva, Vera Böhler, Philip Stork, Björn Engelke, Laura Hamacher, Alexandra Sawadogo, Richard Marc Diederich ...

Published in The Journal of Organic Chemistry

Four tetrahydroxanthone dimers (1-4) and four biogenetically related monomers (5-8), including the new derivatives (4-6), were isolated from the endophyte Phomopsis longicolla. The absolute configurations of 2-4 were established for the first time by TDDFT ECD calculations and that of phomoxanthone A (1) was revised by X-ray crystallography. Phomox...

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