The Ah Receptor Recruits IKK to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcr...
Published in Toxicological Sciences
Aryl hydrocarbon receptor (AHR) activation by xenobiotic ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is key to their toxicity. Following activation and nuclear translocation, AHR heterodimerizes with the AHR nuclear translocator (ARNT) and binds to AHR response elements (AhREs) in the enhancer of target genes, of which Cyp1a1 is the ...
